DYRK3 Back

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3

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NCBI Description of DYRK3

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DYRK3 is highly significantly mutated in
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DYRK3 is significantly mutated in
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DYRK3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for DYRK3