DUSP11 Back

dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of DUSP11

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism.

Community Annotation of DUSP11 Add / Edit DUSP11: Annotations

No community annotations yet for DUSP11.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DUSP11 is highly significantly mutated in
DUSP11 is significantly mutated in
DUSP11 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DUSP11