DUS2L Back

dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of DUS2L
This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene.

Community Annotation of DUS2L Add / Edit DUS2L: Annotations

No community annotations yet for DUS2L.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DUS2L is highly significantly mutated in
(none)
DUS2L is significantly mutated in
(none)
DUS2L is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DUS2L