DRD2 Back

dopamine receptor D2

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NCBI Description of DRD2
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.

Community Annotation of DRD2 Add / Edit DRD2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DRD2 is highly significantly mutated in
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DRD2 is significantly mutated in
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DRD2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DRD2