DRD2 Back

dopamine receptor D2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of DRD2

This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.

Community Annotation of DRD2 Add / Edit DRD2: Annotations

No community annotations yet for DRD2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DRD2 is highly significantly mutated in
DRD2 is significantly mutated in
DRD2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DRD2