DPP6 Back

dipeptidyl-peptidase 6

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NCBI Description of DPP6

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Community Annotation of DPP6 Add / Edit DPP6: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DPP6 is highly significantly mutated in
DPP6 is significantly mutated in
DPP6 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DPP6