DPM1 Back

dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit

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NCBI Description of DPM1
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2.

Community Annotation of DPM1 Add / Edit DPM1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DPM1 is highly significantly mutated in
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DPM1 is significantly mutated in
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DPM1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DPM1