DPH3 Back

DPH3, KTI11 homolog (S. cerevisiae)

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NCBI Description of DPH3
This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform.

Community Annotation of DPH3 Add / Edit DPH3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DPH3 is highly significantly mutated in
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DPH3 is significantly mutated in
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DPH3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DPH3