DPH2 Back

DPH2 homolog (S. cerevisiae)

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NCBI Description of DPH2
This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of DPH2 Add / Edit DPH2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DPH2 is highly significantly mutated in
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DPH2 is significantly mutated in
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DPH2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DPH2