DPEP1 Back

dipeptidase 1 (renal)

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NCBI Description of DPEP1
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DPEP1 is highly significantly mutated in
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DPEP1 is significantly mutated in
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DPEP1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DPEP1