DOT1L Back

DOT1-like, histone H3 methyltransferase (S. cerevisiae)

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NCBI Description of DOT1L
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of DOT1L Add / Edit DOT1L: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DOT1L is highly significantly mutated in
(none)
DOT1L is significantly mutated in
(none)
DOT1L is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DOT1L