dolichol kinase

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of DOLK

The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.

Community Annotation of DOLK Add / Edit DOLK: Annotations

No community annotations yet for DOLK.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DOLK is highly significantly mutated in
DOLK is significantly mutated in
DOLK is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DOLK