DOK2 Back

docking protein 2, 56kDa

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NCBI Description of DOK2
The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.

Community Annotation of DOK2 Add / Edit DOK2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DOK2 is highly significantly mutated in
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DOK2 is significantly mutated in
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DOK2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DOK2