DOHH Back

deoxyhypusine hydroxylase/monooxygenase

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NCBI Description of DOHH
This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.

Community Annotation of DOHH Add / Edit DOHH: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DOHH is highly significantly mutated in
(none)
DOHH is significantly mutated in
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DOHH is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DOHH