DOCK8 Back

dedicator of cytokinesis 8

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NCBI Description of DOCK8
This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Community Annotation of DOCK8 Add / Edit DOCK8: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DOCK8 is highly significantly mutated in
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DOCK8 is significantly mutated in
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DOCK8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DOCK8