DOCK7 Back

dedicator of cytokinesis 7

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NCBI Description of DOCK7
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene.

Community Annotation of DOCK7 Add / Edit DOCK7: Annotations

No community annotations yet for DOCK7.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DOCK7 is highly significantly mutated in
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DOCK7 is significantly mutated in
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DOCK7 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DOCK7