DOCK4 Back

dedicator of cytokinesis 4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of DOCK4

This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized.

Community Annotation of DOCK4 Add / Edit DOCK4: Annotations

No community annotations yet for DOCK4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DOCK4 is highly significantly mutated in
(none)
DOCK4 is significantly mutated in
(none)
DOCK4 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for DOCK4