NCBI Description of DOCK2
|The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection.|
Community Annotation of DOCK2 Add / Edit DOCK2: Annotations
No community annotations yet for DOCK2.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.