DNAJC19 Back

DnaJ (Hsp40) homolog, subfamily C, member 19

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NCBI Description of DNAJC19

The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 2, 6, 10, 14 and 19.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DNAJC19 is highly significantly mutated in
DNAJC19 is significantly mutated in
DNAJC19 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DNAJC19