DNAJB8 Back

DnaJ (Hsp40) homolog, subfamily B, member 8

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NCBI Description of DNAJB8
The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DNAJB8 is highly significantly mutated in
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DNAJB8 is significantly mutated in
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DNAJB8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DNAJB8