DMXL2 Back

Dmx-like 2

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NCBI Description of DMXL2
This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of DMXL2 Add / Edit DMXL2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DMXL2 is highly significantly mutated in
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DMXL2 is significantly mutated in
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DMXL2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DMXL2