DMRT1 Back

doublesex and mab-3 related transcription factor 1

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NCBI Description of DMRT1
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.

Community Annotation of DMRT1 Add / Edit DMRT1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DMRT1 is highly significantly mutated in
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DMRT1 is significantly mutated in
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DMRT1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DMRT1