DLX5 Back

distal-less homeobox 5

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NCBI Description of DLX5

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DLX5 is highly significantly mutated in
DLX5 is significantly mutated in
DLX5 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DLX5