DLL3 Back

delta-like 3 (Drosophila)

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NCBI Description of DLL3

This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DLL3 is highly significantly mutated in
(none)
DLL3 is significantly mutated in
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DLL3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for DLL3