DLG4 Back

discs, large homolog 4 (Drosophila)

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NCBI Description of DLG4
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of DLG4 Add / Edit DLG4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DLG4 is highly significantly mutated in
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DLG4 is significantly mutated in
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DLG4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DLG4