DLG3 Back

discs, large homolog 3 (neuroendocrine-dlg, Drosophila)

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NCBI Description of DLG3

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described.

Community Annotation of DLG3 Add / Edit DLG3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DLG3 is highly significantly mutated in
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DLG3 is significantly mutated in
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DLG3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for DLG3