DKK3 Back

dickkopf homolog 3 (Xenopus laevis)

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NCBI Description of DKK3
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.

Community Annotation of DKK3 Add / Edit DKK3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DKK3 is highly significantly mutated in
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DKK3 is significantly mutated in
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DKK3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DKK3