DKK2 Back

dickkopf homolog 2 (Xenopus laevis)

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NCBI Description of DKK2
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).

Community Annotation of DKK2 Add / Edit DKK2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DKK2 is highly significantly mutated in
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DKK2 is significantly mutated in
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DKK2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DKK2