NCBI Description of DKK2
|This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).|
Community Annotation of DKK2 Add / Edit DKK2: Annotations
No community annotations yet for DKK2.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.