DKK1 Back

dickkopf homolog 1 (Xenopus laevis)

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NCBI Description of DKK1

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Community Annotation of DKK1 Add / Edit DKK1: Annotations

No community annotations yet for DKK1.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DKK1 is highly significantly mutated in
DKK1 is significantly mutated in
DKK1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DKK1