DIX domain containing 1

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NCBI Description of DIXDC1

The protein encoded by this gene is a positive regulator of the Wnt signaling pathway and interacts with AXIN1, DVL2, and MAP3K1. The encoded protein is found associated with gamma tubulin at the centrosome. Three transcript variants, two protein-coding and the other non-protein coding, have been found for this gene. The longer isoform also associates with actin stress fibers while the shorter isoform does not.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DIXDC1 is highly significantly mutated in
DIXDC1 is significantly mutated in
DIXDC1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DIXDC1