DISC1 Back

disrupted in schizophrenia 1

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NCBI Description of DISC1

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Community Annotation of DISC1 Add / Edit DISC1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DISC1 is highly significantly mutated in
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DISC1 is significantly mutated in
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DISC1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for DISC1