DICER1 Back

dicer 1, ribonuclease type III

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NCBI Description of DICER1
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.

Community Annotation of DICER1 Add / Edit DICER1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DICER1 is highly significantly mutated in
(none)
DICER1 is significantly mutated in
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DICER1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DICER1