DIABLO Back

diablo homolog (Drosophila)

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NCBI Description of DIABLO
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DIABLO is highly significantly mutated in
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DIABLO is significantly mutated in
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DIABLO is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DIABLO