DHX8 Back

DEAH (Asp-Glu-Ala-His) box polypeptide 8

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of DHX8

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is highly homologous to yeast Prp22. This protein facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.

Community Annotation of DHX8 Add / Edit DHX8: Annotations

No community annotations yet for DHX8.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DHX8 is highly significantly mutated in
(none)
DHX8 is significantly mutated in
(none)
DHX8 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for DHX8