DHX36 Back

DEAH (Asp-Glu-Ala-His) box polypeptide 36

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NCBI Description of DHX36

This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms.

Community Annotation of DHX36 Add / Edit DHX36: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DHX36 is highly significantly mutated in
DHX36 is significantly mutated in
DHX36 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DHX36