DHODH Back

dihydroorotate dehydrogenase

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NCBI Description of DHODH
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane.

Community Annotation of DHODH Add / Edit DHODH: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DHODH is highly significantly mutated in
(none)
DHODH is significantly mutated in
(none)
DHODH is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DHODH