dihydrofolate reductase

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of DHFR

Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.

Community Annotation of DHFR Add / Edit DHFR: Annotations

No community annotations yet for DHFR.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DHFR is highly significantly mutated in
DHFR is significantly mutated in
DHFR is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DHFR