DHDDS Back

dehydrodolichyl diphosphate synthase

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NCBI Description of DHDDS

The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Community Annotation of DHDDS Add / Edit DHDDS: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DHDDS is highly significantly mutated in
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DHDDS is significantly mutated in
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DHDDS is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for DHDDS