diacylglycerol kinase, delta 130kDa

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NCBI Description of DGKD

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.

Community Annotation of DGKD Add / Edit DGKD: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DGKD is highly significantly mutated in
DGKD is significantly mutated in
DGKD is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DGKD