diacylglycerol kinase, alpha 80kDa

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NCBI Description of DGKA

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

Community Annotation of DGKA Add / Edit DGKA: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DGKA is highly significantly mutated in
DGKA is significantly mutated in
DGKA is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DGKA