DGCR8 Back

DiGeorge syndrome critical region gene 8

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NCBI Description of DGCR8

This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants.

Community Annotation of DGCR8 Add / Edit DGCR8: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DGCR8 is highly significantly mutated in
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DGCR8 is significantly mutated in
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DGCR8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for DGCR8