DERL3 Back

Der1-like domain family, member 3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of DERL3
The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Community Annotation of DERL3 Add / Edit DERL3: Annotations

No community annotations yet for DERL3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DERL3 is highly significantly mutated in
(none)
DERL3 is significantly mutated in
(none)
DERL3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DERL3