DEK Back

DEK oncogene (DNA binding)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of DEK
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of DEK Add / Edit DEK: Annotations

No community annotations yet for DEK.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DEK is highly significantly mutated in
(none)
DEK is significantly mutated in
(none)
DEK is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DEK