DEGS1 Back

degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)

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NCBI Description of DEGS1
This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor.

Community Annotation of DEGS1 Add / Edit DEGS1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DEGS1 is highly significantly mutated in
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DEGS1 is significantly mutated in
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DEGS1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DEGS1