DDX58 Back

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

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NCBI Description of DDX58

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DDX58 is highly significantly mutated in
DDX58 is significantly mutated in
DDX58 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DDX58