DDX21 Back

DEAD (Asp-Glu-Ala-Asp) box polypeptide 21

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of DDX21

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.

Community Annotation of DDX21 Add / Edit DDX21: Annotations

No community annotations yet for DDX21.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DDX21 is highly significantly mutated in
(none)
DDX21 is significantly mutated in
(none)
DDX21 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for DDX21