DDOST Back

dolichyl-diphosphooligosaccharide-protein glycosyltransferase

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NCBI Description of DDOST
This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.

Community Annotation of DDOST Add / Edit DDOST: Annotations

No community annotations yet for DDOST.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DDOST is highly significantly mutated in
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DDOST is significantly mutated in
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DDOST is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DDOST