DCTN5 Back

dynactin 5 (p25)

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NCBI Description of DCTN5
This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DCTN5 is highly significantly mutated in
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DCTN5 is significantly mutated in
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DCTN5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DCTN5