DCTN3 Back

dynactin 3 (p22)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of DCTN3
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.

Community Annotation of DCTN3 Add / Edit DCTN3: Annotations

No community annotations yet for DCTN3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DCTN3 is highly significantly mutated in
(none)
DCTN3 is significantly mutated in
(none)
DCTN3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DCTN3