DCTD Back

dCMP deaminase

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NCBI Description of DCTD
The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of DCTD Add / Edit DCTD: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DCTD is highly significantly mutated in
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DCTD is significantly mutated in
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DCTD is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DCTD