dCMP deaminase

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of DCTD

The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of DCTD Add / Edit DCTD: Annotations

No community annotations yet for DCTD.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


DCTD is highly significantly mutated in
DCTD is significantly mutated in
DCTD is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for DCTD