DCLRE1C Back

DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)

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NCBI Description of DCLRE1C
This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA).

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

DCLRE1C is highly significantly mutated in
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DCLRE1C is significantly mutated in
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DCLRE1C is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for DCLRE1C